plos pathogens acceptance rate

Golden Syrian Hamsters were the definitive host. A full list of our publication fees, funding initiatives and fee assistance information is available here. All other groups expressed similar, expected sensitivity levels to 610 treatments A.3. 13.0 days The average number of days from manuscript submission to the initial editorial decision on the article. In the published article, figures are inserted according to the placement of their first citation and caption in the article. They have fewer requirements than figures that are included in the main article, and they need to be uploaded separately. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Michael Tidwell, The number of harvested worms from each treatment group were compared to untreated mice. INTRODUCTION. Read More. In Photoshop, select LZW compression and Discard Layers, and Save a Copy.. Under our Community Action Publishing model for PLOS Biology, PLOS Medicine and PLOS Sustainability and Transformation authors will only incur fees if their institutions are not members of the journal's collective action community. The p-value threshold for each derivative compared to DMSO was <0.001. Human schistosomiasis is caused mainly by three major species: S. mansoni, S. haematobium, and S. japonicum. The average acceptance rate of PLoS ONE journal is 46%. Prism/unpaired t test (P<0.05). 45-minute exposure mimics the exposure time in a human All screens were performed in experimental and biological triplicate. Worms were observed daily up to 14 days. All PLOS journals are widely indexed by major services such as Crossref, Dimensions, DOAJ, Google Scholar, PubMed, PubMedCentral, Scopus, and Web of Science. The DALYs index (Disability-Adjusted Life Years) for schistosomiasis is estimated at 1.9 million [7]. When naming your figures, matchthe figure file name andthe caption label withthecorresponding in-text citationsin the manuscript. We have tested the ability of OXA and OXA derivatives: 830, 610 and 303 to kill both schistosome genders. Many institutions already support their researchers by setting aside financial resources to cover or reduce the cost of their Open Access publications. Read the full licenses and copyright policy.. These results were encouraging for evaluating 303 performance in animals (Fig 6). There is growing momentum to encourage Open Access publishing through funding initiatives. The temptation of image manipulation, Unmarked grouping of images that should otherwise have been presented separately (for example, from different parts of the same gel, or from different gels, fields, or exposures), EXAMPLES: See Figures 2and 6ofWhats in a picture? Shift + Ctrl + C. Place all panels from a multi-part figure into a single page and single file: A 2-point white space border around each figure is recommended to prevent inadvertent cropping of content at layout. %make the background white Previous treatment of S. mansoni included the use of oxamniquine (OXA), a drug that is activated by a schistosome sulfotransferase (SULT). All PLOS journals comply with major funder requirements for Open Access sharing so authors dont need to worry about their articles eligibility. To evaluate the ability of OXA derivatives to kill S. haematobium and S. japonicum in animal models 5 hamsters per group were infected with 100 cercariae and maintained for 90 dpi and 30 dpi, respectively. Cite figures in ascending numeric order upon first appearance in the manuscript file. PLOS ONE staff and our expert board of Academic Editors work together to ensure that the peer review process is fair, fast and thorough and that the work we publish meets high ethical and methodological standards in line with our editorial policies. Chemical Structure Of CIDD-066790, CIDD-0149830, CIDD-0150610, and CIDD-0150303. A study by Cioli et al. OXA Derivatives Against Schistosoma Species In Vitro Results. Treated PZQ-resistant parasites (PZQ-R) with 830 [28], 610 and 303 results in 100% killing in vitro (Fig 8). Digital images in manuscripts nearing acceptance for publication may be scrutinized for any indication of improper manipulation. Authors from Group B countries who need additional support should apply for PLOS Publication Fee Assistance (below) instead of Research4Life. Publication in any PLOS journal is free for authors whose research is funded primarily (50% or more of the work contained within the article) by an institution located in a Research4Life Group A country. CIDD-0150610: SmSULT RNAi alone, Irrelevant RNAi, and SmSULT RNAi + 610 had 90%+ survival and were displaying healthy characteristics. All other groups expressed similar, expected sensitivity levels to 830 treatments A.2. Also, complete or partial fee waivers can be obtained for authors who do not have funds to cover the fees. Five mice per group were infected with 100 cercaria of S. mansoni. Schistosoma has a complex life cycle that involves freshwater snails as intermediate hosts and humans among others as a final host. Center for Innovative Drug Discovery, Department of Chemistry, University of Texas at San Antonio; San Antonio, Texas, Unites States of America. You can email the site owner to let them know you were blocked. For example, if a vertical image is submitted in a horizontal orientation, it will be set horizontally in the article. Compliance with editorial policies and ethical standards. PLOS is a nonprofit, Open Access publisher empowering researchers to accelerate progress in science and medicine by leading a transformation in research communication. Observation included notes on worm health, viability; lack of motility, shedding of tegument, blebbing of tegument, internal vacuolization, lethargy, and being opaque [38]. This website is using a security service to protect itself from online attacks. The collection draws on the opinion of experts in the field of genetics, who look back at Mendel's original research and examine how well it stands up to modern views on genetics, and how it has. However, upon binding, the compounds do not appear to alter the protein structure significantly in the active site or overall. From the File menu in SigmaPlot, select Print. OXA and OXA derivatives were tested against 10 adults of single sex- female and male worms and female and male worms in worm pairs per well. Initial quality checks are performed to identify potential issues such as: Submissions may be returned to authors for changes or clarifications at this stage. We previously identified CIDD-0149830 (referred to as 830) that shows 100% pan-specific killing activity in vitro. Ability of OXA And OXA Derivatives to Kill Schistosoma Species at Final Concentrations of 143 m, 71.5 m, 35.75 m, And 14.3 m Per Well In Vitro. What is the impact factor of PLOS ONE? Color Mode: RGB eProofs are considered the final form of the paper; authors are encouraged to keep changes to a minimum. Cite figures with the format: Fig 1A, Fig 1B, Fig 2, Fig 3, etc. When adjusting the figure dimensions, be sure the Chain/Lock symbol is closed. Five Balb/c mice per group were infected with 80 cercaria S. mansoni and maintained for 45 dpi, then treated by gavage with single oral dose of 100 mg/kg of OXA derivatives dissolved in 5% DMSO and 95% ethanol. Manuscripts received last year 2569 manuscripts. Submission Experiences 1 2 3 4 Popular Journals PLoS Pathogens Similar Journals If your figures have numerous pictures, charts, or small text, they will render best at a resolution of 600 dpi. These data show using a dose of 71.5 M of 610 and 303 was sufficient to kill 100% of S. mansoni, S. haematobium, and S. japonicum. All drugs were solubilized in 100% DMSO. The action you just performed triggered the security solution. The RNA was left at this step overnight. Most researchers hope to publish in well-known journals with high impact factors. Journal timings vary by subject area and manuscript, we transparently display our timings below as a guide but please be advised this may not reflect our most up-to-date improvements. Your figures contain three elements: figure files, captions, and in-text citations. Export to SVG (Windows Version only). Five mice per group were infected with 80 S. mansoni cercariae, treated with 303 at 100 mg/kg as a single oral dose on 20 dpi, 25 dpi, 28 dpi and 32 dpi and perfused 45 dpi. At 20 dpi, worm burden reduction was not significant. From these, we were able to identify CIDD-0066790 and its (R)-enantiomer CIDD0072229, both of which demonstrated broad species killing activity: S. mansoni (75%), S. haematobium (40%) and S. japonicum (83%) and S. mansoni (93%), S. haematobium 95% and S. japonicum 80%, respectively in an in vitro killing assay [27,28]. Survival was plotted as a percentage over time using Prism/Curve Comparison/ Long-rank (Mantel-cox) test. PLOS publication decisions are based solely on editorial criteria. Improving the formulation to enhance aqueous solubility, extend release and prolong uptake will enhance OXA-derivative treatment. Paired male worms were less susceptible to OXA (Fig 3). To understand how OXA derivatives fit in the SULT binding pocket, X-ray crystal structures of CIDD-0150303 and CIDD-0150610 demonstrate that the SULT active site will accommodate further modifications to our most active compounds as we fine tune them to increase favorable pharmacokinetic properties. Source Normalized Impact per Paper (SNIP) Source Normalized Impact per Paper (SNIP) measures contextual citation impact by weighting citations based on the total number of citations in a subject field. This experiment was a confirmation of our previous work [22] that demonstrates the mode of action of OXA and OXA derivates is the same, due to limited number of worms (n = 30), we performed qPCR only once therefore we didnt show the figures. In contrast to OXA, the PZQ mode of action was not completely understood [41], until recently [31,32]. As of early 2017, PLOS Medicine invited full submissions from about 20% of initial submissions and published approximately 50% of full submissions as research articles. A. CIDD-0149830, B. CIDD-0150610, and C. CIDD-0150303 OXA derivatives were tested against cercaria, 3-hour schistosomula, and male worms for 20 dpi, 25 dpi, 28 dpi, 32 dpi and 45 dpi. Researchers at these institutions will never be subject to fees at these journals. NOTE: Supporting Information figures should not be processed through PACE. We evaluated the efficacy of the best OXA derivates in an in vivo model after treatment with a single dose of 100 mg/kg by oral gavage. You will not be able to change your text after it has been converted to outlines. Describe each part of a multipart figure with with a lettered panel label:for example, (A) or (a). This might be associated with the level of SmSULT transcript. PLOS is working to lower financial barriers to publication through our institutional partnership models. Authors whose research funder is based in a Reserach4Life Group B country also publish for free in PLOS Biology, PLOS Climate, PLOS Global Public Health, PLOS Medicine, PLOS Sustainability and Transformation and PLOS Water. Similar to male worms, female worms SmSULT transcript increases in 21 dpi, peaks at day 28 dpi, but then begins to decrease [36,37]. Calcineurin is required for the formation of appressoria and there- 303 reduced the number of harvested worms by 81.8% (P = 0.017) compared to the negative control (Fig 4A). To create a multi-panel figure from individual files, use a presentation program such as OpenOffice Impress,MicrosoftPowerPoint, or Keynote for Mac. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. Obtaining these crystals required pre-incubating apo SmSULT with CIDD compounds prior to adding PAP, which suggests that PAP stabilizes the enzyme structure thereby limiting access to the active site for our larger, branched compounds. Kaplan-Meier Curves Demonstrate the Ability of OXA Derivatives to Kill All Life Stages of, OXA Derivatives Significantly Reduced the Number of Collected, Crystal Structures of CIDD-0150303 (Left Panel) And CIDD-0150610 (Right Panel) Shown in The Active Site of, Kaplan-Meier Curves Demonstrate the Ability of CIDD-0149. Oxamniquine (OXA) is a drug that was used previously to treat millions of people with S. mansoni with cure rates similar to PZQ [18, 19]. Depending on Schistosoma species and the required stages for each experiment, the infected hamsters were sacrificed between 30 to 90 days post-infection (dpi) in accordance with IACUC protocol (UTHSCSA IACUC Protocol #08039). The parasites where SULT was knocked down were resistant to drug treatment compared to controls, confirming that the mode of action is conserved [28] (S2 Fig). All derivatives were solubilized in 100% DMSO. A. OXA to kill both genders of S. mansoni B. CIDD-0149830 against both genders of B.1. For example, we synthesized two compounds, 303 and 610 with branched indole and (trifluoromethyl)phenyl moieties that swap positions between their binding modes (Fig 7). Secondary structure elements in front of the compounds were omitted for clarity. This is a provisional acceptance, pending final checks for formatting and technical requirements. PLOS Pathogens publishes Open Access research and commentary that significantly advance the understanding of pathogens and how they interact with host organisms. PLoS Pathogens - Impact Factor, Acceptance Rate, Submission - Editage PLoS Pathogens | & - Academic Accelerator Open access status SmSULT:CIDD-0150610 crystals were grown at 4C in Anatrace MCSG-3 condition A1 (20% PEG 8000, 0.1 M HEPES:NaOH pH 7.5). Criteria for Publication. Select all (Ctrl + A) However, OXA reduced the number of worms by 93% P = 0.0002 (Fig 4A). Publishing FAQs - PLOS S4 Table. In order to determine the minimum dose for those derivatives that demonstrate the best killing (100%) of the three species within 14 days of incubation, we evaluated a dose response using 143 M, 71.5 M, 35.75 M and 14.3 M to determine the best concentration for killing. SmSULT was prepared as previously described [22]. CIDD-0149830: SmSULT RNAi alone, Irrelevant RNAi, SmSULT RNAi + OXA, and SmSULT RNAi + 830 had 93%+ survival and were displaying healthy characteristics. Information about applications for fee assistance are not disclosed to journal editors or reviewers. https://doi.org/10.1371/journal.pgen.1005171. doi:10.1371/journal.ppat.1011018, Editor: David L. Williams, Rush University Medical Center, UNITED STATES, Received: November 22, 2022; Accepted: May 31, 2023; Published: July 10, 2023. In cases where PACE cannot process your figure file, the tool will provide you with a report of what it could not fix. The root-mean-square deviation for the 303 complex compared to OXA-bound SmSULT [40] is 0.50 over 1665 atoms and for the 610 complex, 0.16 over 1704 atoms calculated using PyMOL. Use Photoshop orGIMP to edit your figure. PLoS Pathogens Journal Acceptance Rate Feedback System PLoS Pathogens 78.9% The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This study proposes a framework on the simple idea that people decompose tasks to reduce the overall cost of planning while maintaining task performance. Drugs were incubated with schistosomes at 37C, 5% CO2 for 45 minutes, mimicking physiological conditions [22]. Now click on the Page Size tab. The worms were treated for 45 minutes, washed 3 times with media. In my humble opinion, and quite extensive experience in academia, MDPI is not a reputable publisher, in general, and on average, in the sense that: having papers in an MDPI journal does not strengthen one's CV (and tenure, and promotion cases, on average), and also. E. Percentages of worm killing. S2 Table. Survival was plotted as a percentage over time using Prism/Curve Comparison/ Long-rank (Mantel-cox) test. 06/21/2023. For full functionality of this site, please enable JavaScript. The PCR product with T7 promoters were used as a template for transcription of the dsRNA. S. mansoni, B.2. Authors must indicate they require Research4Life fee assistance at the time of manuscript submission. M. oryzae infects plant leaves through specialized structures called appressoria. In this study we have identified an additional two derivatives that show 100% pan-specific killing activity after treatment for 45 minutes at a final concentration of 143 M in vitro (Fig 1), CIDD-0150610 (referred to as 610) and CIDD- 0150303 (referred to as 303) of which 303 is an enantiomer of 830 (S1 Table). Currently, there is no effective vaccine against human schistosomiasis. S. japonicum at 30 days, S. mansoni at 45 days and S. haematobium at 90 days. S. haematobium, and D.3. To help authors broaden their reach both in and outside of their discipline, our dedicated media team works with an extensive network of journalists to highlight noteworthy research. Everything was very fast from the time I sent the article to the time I got the first review and later on with the two rebuttal letters, plus modifications I sent. Research Article $2,841. Fee Assistance FAQs. How to Report Statistics - PLOS Only one treatment, praziquantel (PZQ) is available. (Latest) PLoS ONE Impact Factor 2023 - Journal Impact Factor Therefore, developing a drug that will kill the liver stage schistosomes adds additional value to Schistosoma treatment. PLoS Pathogens - SCI Journal For combination treatment groups mice were treated with single oral dose of PZQ + 610 and PZQ + 303 with 100 mg/kg of each drug. Discover a faster, simpler path to publishing in a high-quality journal. (Consult the SigmaPlot Help files for more details, if needed.). The peer review history package includes the complete editorial decision letter for each revision, with reviews, and your responses to reviewer comments, including attachments. If yourEPS files are still too large, convert them to PDF and then exportto a compressed TIFF. 830 was less effective against S. haematobium and S. japonicum at 71.5 M compared to OXA which kills 40% of S. mansoni at this concentration. Appeals will only be considered when a reviewer or editor is thought to have made a significant factual error or when their objectivity is compromised by a documented competing interest, and when a reversal based on either of these grounds would change the original decision. PLOS Medicine is highly selective; approximately 10% of initial submissions ultimately progress to published articles. The editors consider reviewer feedback and their own evaluation of the manuscript in order to reach a decision. Draw 1458,2757 PLOS Medicine All derivatives were solubilized in 100% DMSO, administered at a final concentration of 143 M per well for 45 minutes, washed 3 timess with media. GIMP and Photoshop will treat it in the same way as they would a PDF. For more detailed guidance, we advise readingWhats in a picture? Where can I find the Editorial Policies and Submission Guidelines for each of the the different PLOS journals? To improve itsresolution, re-create the figure from the beginning. Metrics - PLOS Our focus is drug discovery for schistosomiasis. When submitting an initial or revised manuscript, embed figure captions within the manuscript text after their first mention, or group together at the end of the manuscript. Most OA journals offset publication expenses including the cost of peer review management, journal production, and online hosting and archiving by charging a fee for each article published (APC). Institutional partnerships, either through centralized annual payments, direct-billing or Community Action Publishing membership can eliminate the cost and management of publication fees for many PLOS authors. Ray-traced: Select all (Ctrl + A) Research Matters provides a forum for active scientists to tell the public how diverse fundamental research into pathogens assures real and compelling impact on public health, human knowledge, and life as well as to develop a collective voice of the pathogens research community. Furthermore, 610 and 303 showed significant killing for S. haematobium infection 69.1% and 60%, respectively (Fig 4B). 45-minute exposure mimics the exposure time in a human Each well contained 10 male adult worms. Worms were manually sorted under a dissecting stereomicroscope and aliquoted to 10 single worms or paired worms per well in a 24-well plate. Funding disclosure information provided by authors will be used as part of the PFA application review. The p-value threshold for each derivative compared to DMSO was <0.001. OXA demonstrates the expected level of killing against single-sex males and paired females from S. mansoni, the drug is effective 100% against single-sex females and less effective 60% against paired males. Moreover, previous studies demonstrated a stage-specific susceptibility of S. mansoni to OXA treatment [34,35]. Institutional partnerships, either through centralized annual payments, direct-billing or. This Cookie Policy describes the types of cookies and other tracking technologies we use on the PLOS website, our purposes and basis for using them, and your choices regarding them. Every article we publish provides viewership, downloads, media mentions, social sharing, and citations through Altmetric. CIDD-0149830 against S. mansoni, B.2. Example: afigure file namedFig1.tif should match thecitationFig1 and the figure label Fig 1. in the caption. PLoS Pathogens is a journal published by Public Library of Science.This journal covers the area[s] related to Genetics, Immunology, Microbiology, Molecular Biology, Parasitology, Virology, etc.The coverage history of this journal is as follows: 2005-2021. PLOS One | Impact Factor | Indexing | Acceptance rate | Abbreviation PLOS Pathogens publishes Open Access research and commentary that significantly advance the understanding of pathogens and how they interact with host organisms. If the editors feel that your manuscript has the potential to be published, but requires changes, youll be invited to revise it. In the Print dialogue box that appears, select Adobe PDF as the printer. However, the 20 dpi result was not significant. Throughout the peer review and publication process, PLOS ONE encourages transparency and practices that increase the visibility, trust, and reuse of research. Researchers at these institutions will never be subject to fees at these journals. Paired females were less susceptible to 830. Click on Properties. Dimensions refers to the dimensions of the entire figure, excluding any white space. An author can apply for PFA when submitting an article for publication. The research now focuses on physicochemical, ADME, pharmacokinetics and toxicology studies that will justify requesting authorization from the Food and Drug Administration and ultimately clinical trials. Wecannot publish TIFF figuresthat span multiple pages. The definition of journal acceptance rate is the percentage of all articles submitted to PLoS Pathogens that was accepted for publication. The publishing costs at EMBO - Features - EMBO PLOS now offers accepted authors the opportunity to publish the peer review history of their manuscript alongside the final article. All screens were performed in experimental and biological triplicate. This article proposes an expanded investment framework for Global Health AI and digital health innovation that goes beyond traditional factors such as return on investment and instead proposes non monetary and non GDP metrics, such as Disability Adjusted Life Years or achievement of universal health coverage. Due to the danger of resistance to the monotherapy praziquantel, developing a novel drug will have a significant impact on global human health and will lead to improved treatments for Schistosoma to reduce the morbidity, mortality, and transmission rates associated with these devastating infections. Funding assistance for publication fees are available from many organizations, including PLOS. More and more funders are encouraging researchers to publish in Open Access journals where their work can be read, and shared by all. S. haematobium, and B.3. The structures were determined by the molecular replacement method implemented in PHASER [45] using coordinates from PDB entry 6BDR [27] as the search model. Kaplan-Meier Curves Demonstrate the Ability of OXA Derivatives to Kill Adult Schistosomes. B.3. Color: RGB The infection leads to periportal fibrosis, portal hypertension, liver and spleen enlargement and the serious sequelae of esophageal and upper gastrointestinal varices, recurrent hematemesis, abdominal ascites and urogenital involvement such as, bladder deformity, hydronephrosis, hematuria, female genital schistosomiasis, infertility, increased risk of HIV-1 transmission, and squamous cell carcinoma of the bladder [811]. The tool can also convert figures to TIFF format, resize, and rename figures to our file naming conventions. Praziquantel (PZQ) is the method of choice for treatment. Ray 1458,2757 Publisher: PUBLIC LIBRARY SCIENCE, 185 BERRY ST, STE 1300, SAN FRANCISCO, USA, CA, 94107, INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY. Do not drag/drop or copy/paste images into the file, because this results in a 72 dpi image. S. mansoni, D.2. PLOS Pathogens publishes Open Access research and commentary that significantly advance the understanding of PLoS Pathogens - SciRev identified the gene responsible for OXA resistance [22,23]. Alexander B. Taylor, Knowing the target size of your image in inches and dpi, first convert the number of rows and columns in the image. Submission Experiences 1 2 3 4 5 Popular Journals Ensure that individual images meet the pixel dimensions indicated above when preparing and saving figures withslideshow software (like Powerpoint, OpenOffice, or Keynote).
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